Kernel P systems (or kP systems) bring together relevant features from several P systems flavours into a unified kernel model which allows solving complex problems using a straightforward code programming approach. kPWorkbench is a software suite enabling specification, parsing and simulation of kP systems models defined in the kernel P–Lingua (or kP-Lingua) programming language. It has been shown that any computation of a kP system involving only rewriting and communication rules can be simulated by a family of Communicating Stream X-Machines (or CSXM), which are the core of FLAME agent based simulation environment. Following this, kPWorkbench enables translating kP-Lingua specifications into FLAME models, which can be simulated in a sequential or parallel (MPI based) way by using the FLAME framework. Moreover, FLAME GPU framework enables efficient simulation of CSXM on CUDA enabled GPGPU devices. In this paper we present an extension of kPWorkbench framework to generate FLAME models from kP–Lingua specifications including structural rules; and consider translation of FLAME specifications into FLAME GPU models. Also, we conduct a performance evaluation regarding simulation of equivalent kP systems and CSXM models in kPWorkbench and FLAME respectively.